June 20, 2019

18:00 – 18:10

Opening

László Mátyus, Dean of University of Debrecen

18:10 – 18:40

Key note lecture Up-To-Date: Celiac disease

Ilma Korponay-Szabó

18:40 – 19:00

Poster Session

18:40 – 18:45

Retrospective Blood Pressure profile in pediatric kidney transplant recipients

László Berta1, Adrienn Bárczi1, György Reusz1, Kata Kelen1, Petronella Pethő-Orosz1, Attila Szabó1, Attila Szabó2

1I. Department of Pediatrics, Budapest, 2MTA-SE Pediatric and Nephrology Research Group, Budapest

18:45 – 18:50

Analysis of renal ischaemia-reperfusion induced kidney injury: role of park7

István M. Takács1, Zoltán Kiss2, Beáta Szebeni3, Domonkos Pap3, Apor Veres-Székely1, Marianna Gyurászová4, Erna Sziksz3, Leonóra Balicza-Himer3, Attila Szabó2, Ádám Vannay2

11st Department of Pediatrics, Semmelweis University, 21st Department of Pediatrics, Semmelweis University, MTA-SE Pediatric and Nephrology Research Group, 3MTA-SE Pediatric and Nephrology Research Group, 41st Department of Pediatrics, Semmelweis University, Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

18:50 – 18:55

24-h Holter ECG monitoring in young healthy adults

Petr Tinka1, Pavel Tinka1, Miroslav Novák2, Zuzana Nováková1

1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2First Department of Internal Medicine – Cardioangiology, St Anne´s Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic

18:55 – 19:00

Increasing incidence of IBD based on the prospective nation-wide Hungarian Pediatric IBD Registry (HUPIR)

Zsófia Bodnár, Katalin Eszter Müller, Hungarian IBD Registry Group (HUPIR), Gábor Veres

Dept. Of Pediatrics, University of Debrecen

19:00 – 22:00

Get Together Dinner

June 21, 2019

08:00 – 08:10

Introduction: Past, Present and Future of ES-PCR

08:10 – 09:50

GASTROENTEROLOGY

08:10 – 08:30

Protective role of PARK7 in celiac disease

Apor Veres-Székely1, Domonkos Pap2, Beáta Szebeni2, István M. Takács1, András Arató1, Áron Cseh1, Attila Szabó1, Ádám Vannay2

11st Department of Pediatrics, Semmelweis University, Budapest, 2MTA-SE Pediatric and Nephrology Research Group

08:30 – 08:50

Azathioprine and 5-aminosalycilic-acid impairs ductal epithelial transporter functions in mice

Bálint Tél1, Júlia Nám2, Zoltán Kiss1, Péter Hegyi3, Gábor Veres4, Petra Pallagi2

11st Department of Paediatrics, Semmelweis University, Budapest, Hungary, 2University of Szeged, First Department of Medicine, Szeged, Hungary, 3Institute for Translational Medicine, University of Pécs, Pécs, Hungary, 4University of Debrecen, Paediatric Institute-­Clinic, Debrecen, Hungary

08:50 – 09:10

Diagnostic work-up of paediatric IBD in a nation-wide Hungarian Paediatric Inflammatory Bowel Disease Registry (HUPIR)

Brigitta Tóth, Katalin Eszter Müller, Group HUPIR, Gábor Veres

Department of Pediatric Clinic-Institute, University of Debrecen

09:10 – 09:30

Outcome of pediatric Crohn disease patients after steroid or exclusive enteral nutrition induction – preliminary data based on Hungarian Pediatric IBD Registry (HUPIR)

Veronika Kovacs1, Katalin Muller1, HUPIR Group2, Gabor Veres1

1Department of Pediatrics, University of Debrecen, 2

09:30 – 09:50

Characteristics of body composition, improving physical activity and social functioning in patients with paediatric Crohn’s disease, while patients with ulcerative colitis are balanced from the beginning

Kriszta Katinka Boros1, Katalin Eszter Müller2, Orsolya Cseprekál1, Hajnalka Oláh3, Éva Richter3, Áron Cseh3, Antal Dezsőfi3, András Arató3, György Reusz3, Dóra Dohos3, Gábor Veres2

1Ist Department of Internal Medicine, Semmelweis University, Hungary, 2Pediatric Institute-Clinic of the University of Debrecen , Debrecen , Hungary, 3Ist Department of Paediatrics, Semmelweis University, Hungary

09:50 – 10:10

Coffee break

10:10 – 11:30

ONCOHEMATOLOGY

10:10 – 10:30

Acute promyelocytic leukemia in an infant with variant translocation of RARA gene– impact of multidimensional flow cytometry analysis

Bettina Kárai1, Anikó Ujfalusi1, Imre Gáspár2, Katalin Gyurina2, István Szegedi2, János Kappelmayer1, Zsuzsanna Hevessy1, Csongor Kiss2

1Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Hungary, 2Department of Pediatric Hematology and Oncology, Faculty of Medicine, University of Debrecen, Hungary

10:30 – 10:50

Gene expression profile of B-cell progenitor childhood acute lymphoblastic leukemia according to the expression pattern of coagulation factor XIII subunit A

Katalin Gyurina1, Bettina Kárai1, Anikó Újfalusi1, István Szegedi2, Zsuzsanna Hevessy1, Beáta Scholtz3, János Kappelmayer1, Gábor Zahuczki4, Csongor Kiss2

1Department of Laboratory Medicine, University of Debrecen, Hungary, 2Department of Pediatric Hematology-Oncology, Institute of Pediatrics, University of Debrecen, Hungary, 3Center of Clinical Genomics, Institute of Biochemistry and Molecular Biology, University of Debrecen, Hungary, 4UD-Genomed Medical Genomic Technologies Ltd.

10:50 – 11:10

Characterization of the mTOR pathway and metabolic profile of childhood rhabdomyosarcomas

Luca Felkai1, Dorottya J. Kiss1, Ildikó Krencz2, Dániel Sztankovics2, Tamás Micsík2, Anna Sebestyén2, Monika Csóka1

12nd Department of Pediatrics, Semmelweis University, 21st Department of Pathology and Experimental Cancer Research, Semmelweis University

11:10 – 11:30

HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia

Nóra Kutszegi1, Xiaoqing Yang2, András Gézsi3, Géza Schermann3, Dániel J. Erdélyi1, Ágnes F. Semsei3, Krisztina Míta Gábor4, Judit C. Sági3, Gábor T. Kovács1, András Falus3, Hongyun Zhang5, Csaba Szalai3

12nd Department of Paediatrics, Semmelweis University, Budapest, Hungary, 2BGI-Shenzhen, Shenzhen 518083, China, 3Dept. of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, 4Dept. of Pediatrics and Pediatric Health Care Center, Faculty of Medicine, University of Szeged, Szeged, Hungary, 5BGI Clinical laboratory, Shenzhen 518083, China

11:30 – 12:50

ENDOCRINOLOGY-PSHICHIATRY

11:30 – 11:50

Oxidative stress: A new potential mechanism of anorexia nervosa

Alexandra Gaál Kovalčíková1, Alžbeta Čagalová1, Ľubica Tichá1, Peter Celec2, Katarína Šebeková2, Ľudmila Podracká1

1Department of Pediatrics, National Institute of Children’s diseases and Faculty of Medicine, Comenius University, Bratislava, Slovakia, 2Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

11:50 – 12:10

Motor stereotypies in Autism Spectrum Disorder: a prevalence study and clinical characterization

Claudia Melo1, Tiago Pinto Ribeiro2, Vania Teixeira3, Teresa Temudo4

1Child Neurology Unit, Pediatric Department, Centro Hospitalar do São João, Porto (Portugal); Centre for Health Technology and Services Research (CINTESIS) & Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of M, 2PIN - Progresso infantil, Porto (Portugal), 3Child Psychiatry Department, Centro Hospitalar do Porto Porto (Portugal), 4Child Neurology Unit, Pediatric Department, Centro Materno Infantil do Norte, Centro Hospitalar do Porto, Porto (Portugal); Instituto de Ciências Biomédicas de Abel Salazar, Porto (Portugal)

12:10 – 12:30

The role of serotonin and vitamin D in relationship to obesity and blood pressure regulation in children

Katarína Krivošíková1, Katarína Prochotská1, László Kovács in memoriam1, Zora Krivošíková2

1Department of Paediatrics, Faculty of Medicine at Comenius University and National Institute of Children’s Diseases, Bratislava, 2Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava

12:30 – 12:50

Some biochemical and genetic differences between obese and non-obese hypertensive children and adolescents

Martina Filipič1, Mirjam Močnik2, Boris Zagradišnik3, Nataša Marčun Varda1

1Division of Paediatrics, Unit for nephrology and arterial hypertension, Medical Centre Maribor, Maribor, Slovenia; Medical Faculty Maribor, University of Maribor, Maribor, Slovenia, 2Division of Paediatrics, Unit for nephrology and arterial hypertension, Medical Centre Maribor, Maribor, Slovenia, 3Laboratory of Medical Genetics, Medical Centre Maribor, Maribor, Slovenia; Medical Faculty Maribor, University of Maribor, Maribor, Slovenia

12:50 – 13:40

Lunch

13:40 – 14:40

NEPHROLOGY

13:40 – 14:00

Importance of brain-derived neurotrophic factor (BDNF) in renal transplantation

Agnes Molnar1, Edgar Szkibinszkij2, Lilla Lenart1, Adam Hosszu3, Illes Kovacs4, Laszlo Wagner5, Andrea Fekete1

1MTA-SE Lendület Diabetes Research Group, Budapest; SE 1st Department of Paediatrics, Budapest, 2MTA-SE Lendület Diabetes Research Group, Budapest; SE Department of Transplantation and Surgery, Budapest, 3MTA-SE Lendület Diabetes Research Group, Budapest, 4SE Department of Ophthalmology, Budapest, 5SE Department of Transplantation and Surgery, Budapest

14:00 – 14:20

EXTRACELLULAR VESICLES IN THE DEVELOPMENT OF PERITONEAL DIALYSIS -ASSOCIATED PERITONEAL FIBROSIS

Beáta Szebeni1, István Márton Takács2, Zoltán Varga3, Domonkos Pap1, Apor Veres-Székely2, Attila J Szabó1, S György Reusz2, Ádám Vannay1

1Ist Department of Pediatrics, Semmelweis University, Pediatrics and Nephrology research group, MTA-SE, Budapest, Hungary, 2Ist Department of Pediatrics, Semmelweis University, 3Biological nanochemistry research group, MTA-TTK, Budapest, Hungary

14:20 – 14:40

The regulation of tight junction proteins in peritoneal dialysis

Eszter Lévai1, Maria Bartosova2, Hanna Jenei1, Betti Schaefer2, Akos Ujszaszi3, Conghui Zhang2, Jin-Ho Lee4, Sotirios Zarogiannis5, Michael Hausmann4, Claus P. Schmitt2

11st Department of Paediatrics, Semmelweis University, Budapest, Hungary, 2Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany, 3Division of Nephrology, University Hospital Heidelberg, Heidelberg, Germany, 4Kirchhoff-Institute for Physics, University of Heidelberg, Heidelberg, Germany, 5Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece

14:40 – 15:40

CARDIOVASCULARIS MEDICINA

14:40 – 15:00

ISCHEMIC PRECONDITIONG WORSENS HYPOXIA-ISCHEMIA IN RAT LIVER SUBMITTED TO A MODEL OF ISCHEMIA-REPERFUSION LEADING TO ISCHEMIC CHOLANGIOPATHY, WHILE TOPICAL HYPOTHERMIA IS PROTECTIVE.

Jorge Luiz dos Santos1, Patrícia Quelhas1, Michele Claire Breton1, Tomaz Grezzana2, Rui Caetano de Oliveira3, Maria Augusta Gomes Cipriano3, Ignacio Verde1

1University of Beira Interior, Portugal, 2Porto de Porto Alegre, Brazil, 3Coimbra University Hospital Centre, Portugal

15:00 – 15:20

Non-invasive estimation of arterial stiffness in healthy and asthmatic children: a pilot study.

Pavel Tinka1, Asya Hansen1, Ksenia Budinskaya1, Vojtěch Svízela1, Jana Svačinová1, Jana Rýdlová2, Hana Hrstková3, Petr Dobšák4, Zuzana Nováková1

1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2Children´s Treatment Center Miramonti, Spa Luhačovice, Czech Republic, 3Department of Children Oncology and Internationale Clinical Research Center, St.Anne´s Faculty Hospital Brno and Faculty of Medicine, MU Brno, Czech Republic, 4Department of Sports Medicine and Rehabilitation, St.Anne´s Faculty Hospital Brno and Faculty of Medicine, MU Brno, Czech Republic

15:20 – 15:40

The prevalence of arterial hypertension in Slovene children and adolescents: a pilot study

Tadej Petek, Tjaša Hertiš Petek, Nataša Marčun Varda

University Medical Centre Maribor, Department of Pediatrics, Ljubljanska ul. 5, 2000 Maribor, Slovenia

15:40 – 15:50

Coffee break

15:50 – 17:10

VARIA

15:50 – 16:10

Formulation and biocompatibility investigation of liquid pharmaceutical dosage forms containing ketoprofen

Dániel Nemes, Nikolett Poczok, Olívia Gréta Nagy, Ildikó Bácskay

University of Debrecen - Department of Pharmaceutical Technology

16:10 – 16:30

Comprehensinve analysis of a newly identified missense mutation in the dystrophin gene

Katalin Koczok1, Gabriella Merő2, Gabriella P. Szabó3, László Madar1, Éva Gombos1, Éva Ajzner4, János András Mótyán5, Tibor Hortobágyi6, István Balogh1

1Division of Clinical Genetics, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2Department of Pediatrics, Jósa András Teaching Hospital, Nyíregyháza, Hungary, 3Department of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 4Central Laboratory, Jósa András Teaching Hospital, Nyíregyháza, Hungary, 5Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 6Division of Neuropathology, Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK

16:30 – 16:50

Genetic revision of the Hungarian cystic fibrosis patients’ cohort

Orsolya Orosz, István Balogh

Division of Clinical Genetics, Department of Laboratory Medicine, University of Debrecen, Debrecen, Hungary

16:50 – 17:10

Comparison of sensitivity of lung ultrasound and chest x-ray imaging for the diagnosis of community-acquired pneumonia in children

Vojko Berce, Anja Pintarič

University Medical Centre Maribor, Clinic of Pediatrics

17:10 – 17:20

Closing remarks